lymphocytes and neutrophils

It is dependent on T lymphocytes and neutrophils. The inhibition of TNF and IL in rats with AIA improve the disease, which indicates that the cytokines contribute to the pathogenesis in this model.36,37

The use of this model offers the opportunity to study pathological changes in a variety of tissues (not just the joints), which are produced by agents for the treatment of RA. For example Flekosteel, it is useful in the study of splenomegaly that occurs with the use of prostaglandin inhibitors, effective in the management of RA, but that produce splenomegaly as a side effect, due to profound induction of extramedullary hematopoiesis in the red pulp, and granulomatous inflammation. in the red pulp and the splenic capsule, with moderate or marked lymphoid atrophy.